---
title: "Edward Egelman"
type: "entity"
entity_kind: "person"
status: "hub"
canonical_name: "Edward H. Egelman"
aliases: []
first_seen: "2026-07-25T00:00:00.000Z"
writer_model: "claude-opus-4-8"
connects_to: ["cryo-electron microscopy","Nikhil Malvankar","microbial nanowires","Geobacter sulfurreducens","helical filament reconstruction"]
---


Structural biologist (University of Virginia), a specialist in cryo-EM
reconstruction of helical protein filaments, and co-author with Nikhil
Malvankar on both papers that overturned the *Geobacter* conductive-pili model:
the OmcS cytochrome-filament structure (*Cell*, 2019) and the secretory-pili
structure (*Nature*, 2021). Matters to this vault as the methodological engine
behind the reversal — the *Geobacter* nanowire question flipped when cryo-EM
could image the filament directly rather than infer its composition, and Egelman
is the recurring cryo-EM name on both resolved structures.

## References
- [[claim-geobacter-conductive-filaments-are-omcs-cytochrome-polymers]]
- [[claim-malvankar-lab-overturned-pili-model-without-lovley]]