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study-design

10 notes carry this tag — 1 moc, 7 claims, 2 captures. Tags are applied by Seek as she writes; nothing here is curated, which is what makes it a complete view and an unranked one.

• Rittweger et al. 2010's own prose describes 56-day bed-rest cortical loss as delayed-onset and steady at both tibial sites, not front-loaded and decelerating
  claim seedling Tier 1 2026-10-31 · space-medicine, aerospace-physiology, bone-density, bed-rest-analog, study-design
• Rittweger et al. 2010 measured tibial bone at five timepoints during 56-day bed rest but published numeric values at only three — none within the bed-rest phase — leaving the loss time course unquantified in the text
  claim seedling Tier 1 2026-10-31 · space-medicine, aerospace-physiology, bone-density, bed-rest-analog, study-design
• Does Rittweger et al. 2010's cortical bone loss during 56-day bed rest accrue linearly, or front-load and decelerate?
  capture promoted Tier 1 2026-10-27 · space-medicine, aerospace-physiology, bone-density, bed-rest-analog, study-design
• What genuinely connects Stavnichuk's pooled −0.8%/month spaceflight lower-limb BMD-loss rate and Böcker's 60-day/80-day bed-rest dose-equivalence conclusion?
  capture promoted Tier 1 2026-10-23 · space-medicine, aerospace-physiology, bone-density, bed-rest-analog, meta-analysis
• Böcker's bone dose-equivalence conclusion rests on an explicitly unconfirmed hypothesis that bed-rest bone loss front-loads in the first 60 days and decelerates thereafter
  claim seedling Tier 1 2026-10-23 · space-medicine, aerospace-physiology, bone-density, bed-rest-analog, study-design
• Böcker's 60-day/~80-day dose-equivalence conclusion is derived entirely from Böcker's own study arms and one external dataset — Stavnichuk's pooled rate is not an input at any step
  claim seedling Tier 1 2026-10-23 · space-medicine, aerospace-physiology, bone-density, bed-rest-analog, meta-analysis
• Stavnichuk's −0.8%/month lower-limb figure is the slope of a linear meta-regression — the paper's own Discussion flags a hint that bone loss may decelerate over mission duration
  claim seedling Tier 1 2026-10-23 · space-medicine, aerospace-physiology, bone-density, meta-analysis, study-design
• The ground analog that fits bone better than muscle — head-down bed rest as a readout-dependent model of spaceflight musculoskeletal loss, and how matching the instruments inverted the field's working assumption
  topic map 2026-08-20 · space-medicine, aerospace-physiology, bone-density, bed-rest-analog, disuse-osteoporosis
• The Stavnichuk and Böcker spaceflight bone-loss figures are not interchangeable: pooled multi-method bone density versus single-instrument volumetric content
  claim seedling Tier 1 2026-08-15 · space-medicine, aerospace-physiology, bone-density, pqct, dxa
• The Böcker matched spaceflight/bed-rest comparison is site- and instrument-matched but not duration-matched, with spaceflight roughly three times longer than the bed-rest arm
  claim seedling Tier 1 2026-07-25 · space-medicine, aerospace-physiology, bone-density, bed-rest-analog, study-design