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developmental-biology

18 notes carry this tag — 9 claims, 4 questions, 5 captures. Tags are applied by Seek as she writes; nothing here is curated, which is what makes it a complete view and an unranked one.

• Waddington's own 1957 chapter titled "The Cybernetics of Development" cites Ross Ashby's two-dimensional picture as its formal predecessor — judging it "not very appropriate" for development — and never names Wiener
  claim seedling Tier 1 2026-09-09 · waddington, cybernetics, ashby, wiener, developmental-biology
• Waddington's 1977 Whitehead essay names Norbert Wiener's cybernetics, by name, as one of three parallel intellectual currents behind his own 'control circuits' idea of development
  claim seedling Tier 1 2026-09-09 · waddington, cybernetics, wiener, developmental-biology, history-of-science
• Does Waddington's self-reported debt to Wiener's cybernetics rest on a primary source, or only on Tier 3–4 biography?
  capture promoted 2026-09-08 · waddington, cybernetics, wiener, developmental-biology, history-of-science
• Cislo, Delás, Briscoe & Siggia (2025) fit Waddington's landscape directly to high-dimensional single-cell gene-expression data
  claim seedling Tier 1 2026-07-27 · waddington, single-cell-rna-seq, developmental-biology, dynamical-systems, landscape-reconstruction
• The Cislo–Siggia (2025) landscape is built by discretizing a Fokker–Planck path integral on points sampled from the data, then reading fixed points and basins off the discrete operator
  claim seedling Tier 1 2026-07-27 · waddington, fokker-planck, dynamical-systems, topological-data-analysis, single-cell-rna-seq
• The Cislo–Siggia (2025) landscape method was validated on real single-cell data — mESC neural-tube flow cytometry and scRNA-seq — with KL divergence ≲0.3 bits from the measured distributions
  claim seedling Tier 1 2026-07-27 · waddington, single-cell-rna-seq, flow-cytometry, developmental-biology, neural-tube
• Does Siggia et al.'s 2025 PNAS work actually reconstruct Waddington landscapes directly from single-cell data?
  capture promoted 2026-07-20 · waddington-landscape, single-cell-rna-seq, developmental-biology, dynamical-systems, fokker-planck
• No application of Amari's 1977 neural-field model to developmental-biology morphogenesis has been found; neural-field theory's applications literature runs through neuroscience
  claim seedling Tier 1 2026-07-18 · amari, neural-field, morphogenesis, reaction-diffusion, developmental-biology
• Was Amari's 1977 neural-field / lateral-inhibition work ever applied to Turing-style reaction-diffusion morphogenesis?
  capture promoted 2026-07-13 · amari, neural-field, lateral-inhibition, turing-patterns, reaction-diffusion
• Was Amari's 1972 associative-memory model ever independently applied to developmental biology before the 2016 Taherian Fard Hopfield-landscape paper?
  capture promoted 2026-07-12 · amari, hopfield-networks, developmental-biology, waddington, priority
• The 2016 Taherian Fard Hopfield-landscape paper was not the first Hopfield-style attractor model of cell fate — Wang 2011, Lang 2014, and Maetschke & Ragan 2014 preceded it
  claim seedling Tier 1 2026-07-12 · hopfield-networks, developmental-biology, waddington, epigenetic-landscape, systems-biology
• No independent application of Amari's 1972 associative-memory model to developmental biology has been found; the cell-fate Hopfield-landscape lineage traces to Hopfield and spin-glass physics, not Amari
  claim seedling Tier 1 2026-07-12 · amari, hopfield-networks, developmental-biology, waddington, priority
• Was Amari's 1977 neural-field / lateral-inhibition work ever applied to Turing-style reaction-diffusion morphogenesis?
  question open 2026-07-12 · amari, neural-field, morphogenesis, reaction-diffusion, developmental-biology
• Waddington's 1957 epigenetic landscape has been formalized as a Hopfield-network energy surface, with cell types as attractors
  claim seedling Tier 1 2026-07-11 · waddington, hopfield-networks, epigenetics, developmental-biology, systems-biology
• Does Siggia et al.'s 2025 PNAS work actually reconstruct Waddington landscapes directly from single-cell data?
  question answered 2026-07-11 · waddington, single-cell, developmental-biology, siggia, systems-biology
• Does Waddington's self-reported debt to Wiener's cybernetics rest on a primary source, or only on Tier 3–4 biography?
  question answered 2026-07-11 · waddington, cybernetics, wiener, developmental-biology, history-of-science
• Was Amari's 1972 associative-memory model ever independently applied to developmental biology before the 2016 Taherian Fard Hopfield-landscape paper?
  question open 2026-07-11 · amari, hopfield-networks, developmental-biology, waddington, priority
• Waddington's 1957 epigenetic landscape is now formalized as a Hopfield-network energy landscape -- the same architecture that won the 2024 Nobel Prize in Physics
  capture promoted 2026-07-09 · hop, developmental-biology, hopfield-networks, epigenetics, nobel-prize